One of the oldest houses in Philadelphia, Wyck is now a non-profit museum listed on the National Register of Historic Places. Nine generations of the Jansen-Wistar-Haines family owned the Wyck property from 1690 until 1973. The last family owner deeded 2.5 acres of land, the house and its contents, several outbuildings, a landscaped garden, and a small endowment to the Wyck Charitable Trust. The Wyck Charitable Trust and the Wyck Association now administer the preservation of the property and its educational services to the public. This collection contains diaries, letters, accounts, bills and receipts, deeds, and photographs. The collection as a whole is deepest for the period 1770-1970. Items of particular note include accounts of household expenses at Wyck from ca. 1790-1970; papers pertaining to the Academy of Natural Sciences of Philadelphia, Quaker schools, and social reform groups; agricultural and horticultural practices; and correspondence to and from cultural leaders of 18th and 19th century Philadelphia. The papers of the John S. Haines family (Ms. Coll. 52A) form part of the Wyck Papers. The papers cover the years 1845 to 1949 and are arranged into eight series.

In addition to family and business correspondence, the Charles Nicoll Bancker Family Papers contains various documents, such as a furniture inventory volume (30pp.); a Daybook, 1795-1800 (120pp.); and a very interesting journal (unidentified, but by one of the Banckers, and filed under "Description of a trip..."), from New York to Albany and back, between July 20-Aug. 15, 1793 (1 vol., 31 pp.). It contains detailed observations of the Hudson River and the towns along the way. Bancker was involved in business and trade prior to 1826, and in insurance after that date, so there is material relating to those topics in this collection. He owned a substantial library of the period, which was used by Charles Wilkes's Expedition after 1837 (see Reynell Coates to Bancker). This library, along with Bancker's notable scientific instrument collection, was sold after his death and there are published auction catalogues in the collection. There is much family correspondence from: Anne E. Bancker, Charles Gerard Bancker, Evert Bancker, Sarah U. Bancker, Violetta Bancker Talbot, Elizabeth Bancker Teackle, and John Teackle.

A collection of business and personal papers of three generations of the prominent Philadelphia Jewish family from 1750-1974. Business records include trade and land transactions (some in Yiddish) of the Gratz brothers, Barnard and Michael (1750-1804) with the business continued by Michael's sons: Simon, Hyman, Joseph, Jacob, and Benjamin (1791-1861). Personal correspondence are primarily letters to Rebecca Gratz from her sisters Rachel and Sarah (1795-1867) with later correspondence to Rachel's children: Horace and Sara Moses (1832-1879). Contains a small group of French letters related to Napoleon III, collected by family member Miriam Fox, and some heirloom artifacts.